Overview
Early detection methods for cancer biomarkers using innovative biosensor technologies.
Early detection is crucial for successful cancer treatment. Our research focuses on developing highly sensitive and specific biosensors for detecting cancer biomarkers at early stages when treatment is most effective.
Research Areas
Tumor Markers
Detection of protein biomarkers associated with various cancers.
- PSA (Prostate cancer)
- CEA (Colorectal cancer)
- CA-125 (Ovarian cancer)
- AFP (Liver cancer)
- HER2 (Breast cancer)
- Cardiac troponins
Circulating DNA
Detection of cell-free tumor DNA (ctDNA) in blood samples.
- Mutation detection
- Methylation analysis
- Copy number variations
- Microsatellite instability
Exosome Detection
Analysis of tumor-derived extracellular vesicles for cancer diagnosis.
- Exosome isolation methods
- Surface marker analysis
- Exosomal miRNA profiling
- Protein cargo analysis
Liquid Biopsy
Non-invasive sampling methods for cancer monitoring.
- Circulating tumor cells (CTCs)
- Cell-free DNA analysis
- Exosome analysis
- Tumor-educated platelets
Güncel proje
Molecularly Imprinted Biosensors for Cancer Biomarkers
Novel molecularly imprinted polymer-based sensors for early detection of circulating tumor markers in blood samples.
Önemli yayınlar
Quartz crystal microbalance based biosensors for detecting highly metastatic breast cancer cells via their transferrin receptors
Seda Atay, K. Piskin, Fatma Yılmaz, Canan Çakır, H. Yavuz, A. Deni̇zli̇
2016 · doi:10.1039/C5AY02898A
Quartz Crystal Microbalance (QCM) Based Biosensor Functionalized by HER2/neu Antibody for Breast Cancer Cell Detection
M. Yılmaz, Monireh Bakhshpour, Ilgım Göktürk, A. K. Pişkin, A. Deni̇zli̇
Biosensing Platforms for Cardiac Biomarker Detection
Zeynep Gerdan, Yeşeren Saylan, A. Deni̇zli̇
ACS Omega 2024 · doi:10.1021/acsomega.3c06571
A molecularly imprinted SPR biosensor for label-free detection of neuron-specific enolase as a cancer biomarker
B. S. Cevrimli, Ayşegül Bülbül, Fatma Yılmaz, Adil Denizli
Microchemical journal (Print) 2026 · doi:10.1016/j.microc.2026.118787