Overview
Advanced molecular diagnostics for rapid and accurate detection of viral pathogens including Ebola, HIV, Zika, and SARS-CoV.
Our virus detection research addresses critical global health challenges by developing rapid, sensitive, and cost-effective diagnostic tools. We focus on creating platforms that can be deployed in both clinical laboratories and resource-limited settings.
Current Focus: Prof. Denizli has edited "Advances in Virus Detection with Sensors" for the Royal Society of Chemistry's Detection Science Series.
Research Areas
Molecular Imprinting
We develop molecularly imprinted polymers (MIPs) that act as synthetic antibodies for specific virus recognition. These materials offer advantages of stability, reusability, and low cost compared to biological antibodies.
- Whole virus imprinting
- Epitope imprinting
- Surface imprinting techniques
- Computational design of MIPs
Aptamer-based Detection
Aptamers are single-stranded DNA or RNA molecules that can bind to specific targets with high affinity. We develop aptamer-based sensors for various viral pathogens.
- SELEX selection of virus-specific aptamers
- Aptamer-functionalized nanoparticles
- Electrochemical aptasensors
- Lateral flow aptamer assays
Nanoparticle Platforms
Nanomaterials enhance sensor performance through signal amplification and improved surface area for biorecognition.
- Gold nanoparticle-based colorimetric detection
- Magnetic nanoparticle concentration
- Carbon nanotube sensors
- Quantum dot labeling
Target Pathogens
- SARS-CoV-2
- Ebola virus
- HIV
- Zika virus
- Hepatitis viruses
- Influenza
- Dengue
- Norovirus
Güncel proje
Point-of-Care Testing Device Development
Collaborative project with industry partner to develop commercial point-of-care diagnostic devices for infectious diseases.
Önemli yayınlar
An Alternative Medical Diagnosis Method: Biosensors for Virus Detection
Yeşeren Saylan, Özgecan Erdem, S. Ünal, A. Deni̇zli̇
Biosensors 2019 · doi:10.3390/bios9020065
Virus detection using nanosensors
Nanosensors for Smart Cities 2020 · doi:10.1016/B978-0-12-819870-4.00038-4
Optical biosensors for virus detection
Biosensors for Virus Detection 2021 · doi:10.1088/978-0-7503-3867-7ch2
Biosensors for Virus Detection
Virus-Based Nanocarriers for Targeted Drug Delivery
Semra Akgönüllü, Monireh Bakhshpour, Yeşeren Saylan, A. Deni̇zli̇
Viral and Antiviral Nanomaterials 2021 · doi:10.1201/9781003136644-11