Molecularly imprinted cryogel membranes for mitomycin C delivery
Pınar Öncel, Kemal Çetin, A. A. Topçu, H. Yavuz, A. Deni̇zli̇
- Yazarlar
- Pınar Öncel, Kemal Çetin, A. A. Topçu, H. Yavuz, A. Deni̇zli̇
- Yayın
- Journal of Biomaterials Science. Polymer Edition 2017
- DOI
- 10.1080/09205063.2017.1282772
- Atıflar
- 30
Özet
In this study, cryogel-based implantable molecularly imprinted drug delivery systems were designed for the delivery of antineoplastic agent. Mitomycin C imprinted poly(2-hydroxyethyl methacrylate-N-methacryloyl-l-glutamic acid) cryogel membranes were produced by free-radical bulk polymerization under partially frozen conditions. The membranes were characterized by swelling tests, Fourier transform infrared spectroscopy, scanning electron microscopy, surface area measurements and in vitro hemocompatibility tests. In vitro delivery studies were carried out to examine the effects of cross-linker ratio and template content. Mitomycin C imprinted cryogel membranes have megaporous structure (10-100 μm in diameter). The cumulative release of mitomycin C was decreased with increasing cross-linking agent ratio and increased with the amount of template in the cryogel structure. The nature of transport mechanism of the mitomycin C from the membranes was non-Fickian.
Bu makaleye atıf yapın
Pınar Öncel, Kemal Çetin, A. A. Topçu, H. Yavuz, A. Deni̇zli̇ (2017). Molecularly imprinted cryogel membranes for mitomycin C delivery. Journal of Biomaterials Science. Polymer Edition. https://doi.org/10.1080/09205063.2017.1282772
BibTeX
@article{pnar2017,
title = {Molecularly imprinted cryogel membranes for mitomycin C delivery},
author = {Pınar Öncel and Kemal Çetin and A. A. Topçu and H. Yavuz and A. Deni̇zli̇},
journal = {Journal of Biomaterials Science. Polymer Edition},
doi = {10.1080/09205063.2017.1282772},
year = {2017}
}