Molecularly imprinted polymer based quartz crystal microbalance sensor system for sensitive and label-free detection of synthetic cannabinoids in urine.

Yazarlar

D. Battal, Semra Akgönüllü, M. Yalçin, H. Yavuz, A. Deni̇zli̇

Yayın

Biosensors & bioelectronics 2018

DOI

10.1016/j.bios.2018.03.055

Atıflar

79

Özet

Herein, we prepared a novel quartz crystal microbalance (QCM) sensor for synthetic cannabinoids (JWH-073, JWH-073 butanoic acid, JWH-018 and JWH-018 pentanoic acid,) detection. Firstly, the synthetic cannabinoid (SCs) imprinted (MIP) and non-imprinted (NIP) nanoparticles were synthesized by mini-emulsion polymerization system. The SCs-imprinted nanoparticles were first characterized by SEM, TEM, zeta-size and FTIR-ATR analysis and then were dropped onto the gold QCM surface. The SCs-imprinted QCM sensor was characterized by an ellipsometer, contact angle, and AFM. The limit of detection was found as 0.3, 0.45, 0.4, 0.2 pg/mL JWH-018, JWH-073, JWH-018 pentanoic acid and JWH-073 butanoic acid, respectively. The selectivity of the SCs-imprinted QCM sensor was shown by using JWH-018, JWH-018 pentanoic acid, JWH-073 and JWH-073 butanoic acid. According to the results, the SCs-imprinted QCM sensors show highly selective and sensitive in a broad range of synthetic cannabinoid concentrations (0.0005-1.0 ng/mL) in both aqueous and synthetic urine solutions.

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BibTeX

@article{d2018,
  title   = {Molecularly imprinted polymer based quartz crystal microbalance sensor system for sensitive and label-free detection of synthetic cannabinoids in urine.},
  author  = {D. Battal and Semra Akgönüllü and M. Yalçin and H. Yavuz and A. Deni̇zli̇},
  journal = {Biosensors & bioelectronics},
  doi     = {10.1016/j.bios.2018.03.055},
  year    = {2018}
}

← Tüm yayınlar DOI: 10.1016/j.bios.2018.03.055