Removal of iron by chelation with molecularly imprinted supermacroporous cryogel

Yazarlar

Duygu Çimen, Ilgım Göktürk, Fatma Yılmaz

Yayın

Artificial Cells Nanomedicine and Biotechnology 2015

DOI

10.3109/21691401.2015.1011810

Atıflar

12

Özet

Iron chelation therapy can be used for the selective removal of Fe(3+) ions from spiked human plasma by ion imprinting. N-Methacryloyl-(L)-glutamic acid (MAGA) was chosen as the chelating monomer. In the first step, MAGA was complexed with the Fe(3+) ions to prepare the precomplex, and then the ion-imprinted poly(hydroxyethyl methacrylate-N-methacryloyl-(L)-glutamic acid) [PHEMAGA-Fe(3+)] cryogel column was prepared by cryo-polymerization under a semi-frozen temperature of - 12°C for 24 h. Subsequently, the template, of Fe(3+) ions was removed from the matrix by using 0.1 M EDTA solution. The values for the specific surface area of the imprinted PHEMAGA-Fe(3+) and non-imprinted PHEMAGA cryogel were 45.74 and 7.52 m(2)/g respectively, with a pore size in the range of 50-200 μm in diameter. The maximum Fe(3+) adsorption capacity was 19.8 μmol Fe(3+)/g cryogel from aqueous solutions and 12.28 μmol Fe(3+)/g cryogel from spiked human plasma. The relative selectivity coefficients of ion-imprinted cryogel for Fe(3+)/Ni(2+) and Fe(3+)/Cd(2+) were 1.6 and 4.2-fold greater than the non-imprinted matrix, respectively. It means that the PHEMAGA-Fe(3+) cryogel possesses high selectivity to Fe(3+) ions, and could be used many times without significantly decreasing the adsorption capacity.

İlgili araştırmalar

BiyosensörlerBiyokromatografiHemoperfüzyon

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BibTeX

@article{duygu2015,
  title   = {Removal of iron by chelation with molecularly imprinted supermacroporous cryogel},
  author  = {Duygu Çimen and Ilgım Göktürk and Fatma Yılmaz},
  journal = {Artificial Cells Nanomedicine and Biotechnology},
  doi     = {10.3109/21691401.2015.1011810},
  year    = {2015}
}

← Tüm yayınlar DOI: 10.3109/21691401.2015.1011810