Biochromatography and Biodiagnostics Research Group · Department of Chemistry, Hacettepe University

Hemoperfusion

Overview

Development of biocompatible sorbents for blood purification and therapeutic applications.

Hemoperfusion is an extracorporeal blood purification technique that removes toxins and other harmful substances from the blood using adsorbent materials. Our research focuses on developing highly selective and biocompatible sorbents for various therapeutic applications.

Historical Note: Prof. Denizli's PhD thesis (1992) was on "Specific Sorbents for Hemoperfusion," establishing our long history in this field.

Research Areas

Toxin Removal

Development of sorbents for removing various toxins from blood in cases of poisoning or organ failure.

  • Drug overdose treatment
  • Uremic toxin removal
  • Bilirubin adsorption
  • Endotoxin removal (sepsis)

Protein Adsorption

Selective removal of pathogenic proteins and autoantibodies from blood.

  • Autoantibody removal
  • β2-microglobulin adsorption
  • LDL apheresis
  • Cytokine removal

Biocompatibility Studies

Ensuring materials are safe for contact with blood.

  • Hemocompatibility testing
  • Protein adsorption studies
  • Platelet activation assessment
  • Complement activation

Polymer Synthesis

Development of novel polymeric materials for hemoperfusion.

  • Cryogels
  • Composite beads
  • Surface-modified polymers
  • Membrane adsorbers

Key publications

All 14 selected publications in this area