Overview
Development of novel biosensor platforms for rapid and sensitive detection of biomarkers, pathogens, and environmental contaminants.
Our biosensor research focuses on creating innovative detection platforms that combine biological recognition elements with physical transducers to achieve highly sensitive and selective measurements. We develop sensors for applications ranging from clinical diagnostics to environmental monitoring and food safety.
Research Areas
Electrochemical Biosensors
We develop electrochemical sensors using various techniques including amperometry, voltammetry, and impedance spectroscopy. These sensors offer advantages of miniaturization, low cost, and real-time monitoring capabilities.
- Enzyme-based electrodes for glucose and lactate detection
- Immunosensors for protein biomarkers
- DNA sensors for genetic analysis
- Aptamer-based electrochemical platforms
Optical Biosensors
Our optical biosensor research includes surface plasmon resonance (SPR), fluorescence-based detection, and colorimetric assays for label-free and real-time biomolecular interaction analysis.
- SPR sensors for kinetic measurements
- Localized SPR using nanoparticles
- Fluorescence resonance energy transfer (FRET)
- Quantum dot-based optical detection
Piezoelectric Sensors
Quartz crystal microbalance (QCM) and surface acoustic wave (SAW) sensors for mass-sensitive detection of biomolecules with high sensitivity.
- QCM immunosensors
- Bacterial detection platforms
- Virus particle quantification
Current project
Point-of-Care Testing Device Development
Collaborative project with industry partner to develop commercial point-of-care diagnostic devices for infectious diseases.
Key publications
l-Histidine imprinted supermacroporous cryogels for protein recognition
Nilay Bereli̇, Yeşeren Saylan, L. Uzun, R. Say, A. Deni̇zli̇
Determination of Cyclic Citrullinated Peptide Antibodies on Quartz Crystal Microbalance Based Nanosensors
Yeşeren Saylan, Fatma Yılmaz, A. Deni̇zli̇
2015
Quartz Crystal Microbalance Based Hydrophobic Nanosensor for Lysozyme Detection
Fatma Yılmaz, Yeşeren Saylan, Ali Derazshamshir, Seda Atay, A. Deni̇zli̇
2015
Synthesis of a specific monolithic column with artificial recognition sites for L-glutamic acid via cryo-crosslinking of imprinted nanoparticles
Ilgım Göktürk, R. Uzek, L. Uzun, A. Deni̇zli̇
Artificial Cells Nanomedicine and Biotechnology 2015 · doi:10.3109/21691401.2015.1011806
Removal of iron by chelation with molecularly imprinted supermacroporous cryogel
Duygu Çimen, Ilgım Göktürk, Fatma Yılmaz
Artificial Cells Nanomedicine and Biotechnology 2015 · doi:10.3109/21691401.2015.1011810
Triazine herbicide imprinted monolithic column for capillary electrochromatography
S. Aşır, Ali Derazshamshir, Fatma Yılmaz, A. Deni̇zli̇
Electrophoresis 2015 · doi:10.1002/elps.201500232