Inspirations of Biomimetic Affinity Ligands: A Review
A. A. Topçu, Seçkin Kılıç, Erdoğan Özgür, Deniz Türkmen, A. Deni̇zli̇
- Authors
- A. A. Topçu, Seçkin Kılıç, Erdoğan Özgür, Deniz Türkmen, A. Deni̇zli̇
- Published
- ACS Omega 2022
- DOI
- 10.1021/acsomega.2c03530
- Citations
- 16
Abstract
Affinity chromatography is a well-known method dependent on molecular recognition and is used to purify biomolecules by mimicking the specific interactions between the biomolecules and their substrates. Enzyme substrates, cofactors, antigens, and inhibitors are generally utilized as bioligands in affinity chromatography. However, their cost, instability, and leakage problems are the main drawbacks of these bioligands. Biomimetic affinity ligands can recognize their target molecules with high selectivity. Their cost-effectiveness and chemical and biological stabilities make these antibody analogs favorable candidates for affinity chromatography applications. Biomimetics applies to nature and aims to develop nanodevices, processes, and nanomaterials. Today, biomimetics provides a design approach to the biomimetic affinity ligands with the aid of computational methods, rational design, and other approaches to meet the requirements of the bioligands and improve the downstream process. This review highlighted the recent trends in designing biomimetic affinity ligands and summarized their binding interactions with the target molecules with computational approaches.
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Cite this article
A. A. Topçu, Seçkin Kılıç, Erdoğan Özgür, Deniz Türkmen, A. Deni̇zli̇ (2022). Inspirations of Biomimetic Affinity Ligands: A Review. ACS Omega. https://doi.org/10.1021/acsomega.2c03530
BibTeX
@article{a2022,
title = {Inspirations of Biomimetic Affinity Ligands: A Review},
author = {A. A. Topçu and Seçkin Kılıç and Erdoğan Özgür and Deniz Türkmen and A. Deni̇zli̇},
journal = {ACS Omega},
doi = {10.1021/acsomega.2c03530},
year = {2022}
}