Nondegradable and Biodegradable Polymeric Particles: Preparation and Some Selected Biomedical Applications

Authors

E. Pişkin, A. Tuncel, A. Deni̇zli̇, E. Denkbaş, Hakan Ayhan, H. Çiçek, K. Xu

Published

1994

DOI

10.1021/BK-1994-0556.CH018

Citations

7

Abstract

This paper summarizes our recent studies related to production of nondegradable and biodegradable polymeric particles and their use in diverse biomedical applications. Nondegradable monosize polystyrene based particles were prepared in micron-size range by a phase inversion polymerization. Surfaces of these particles were then coated with styrene-acrylate copolymer layers in order to include different functional groups. These particles were radiolabeled with 99m Tc succesfully used in animals and in human subjects for diagnostic imaging of GIT. Phagocytosis of these particles and their biologically modified forms by leucocytes and also macrophages were investigated. The polystyrene particles were coated with a cross-linked polyvinylalcohol layer, and then a dye (i.e.,Cibacron blue) was attached for specific protein adsorption. The extents of nonspecific and specific protein (i.e., albumin) adsorption on these particles were presented. Biodegradable monosize polyethylcyanoacrylate particles were prepared by a dispersion polymerization. The effects of several parameters on degradation of these particles were discussed. Biodegradable polylactic acid particles with narrow size distribution were produced by solvent evaporation techniques. A model drug was also loaded in these particles, and its release from these particles were investigated.

Cite this article

BibTeX

@article{e1994,
  title   = {Nondegradable and Biodegradable Polymeric Particles: Preparation and Some Selected Biomedical Applications},
  author  = {E. Pişkin and A. Tuncel and A. Deni̇zli̇ and E. Denkbaş and Hakan Ayhan and H. Çiçek and K. Xu},
  doi     = {10.1021/BK-1994-0556.CH018},
  year    = {1994}
}

← All publications DOI: 10.1021/BK-1994-0556.CH018